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Large molecule neurotransmitters are stored in vesicles in a neuron's soma.

A) True
B) False

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You are a neuroscientist attempting to determine what type of neurotransmitter each releases based on the enzymes found in the neurons.You have so far determined that all of the neurons contain the enzyme tyrosine hydroxylase.Determine which neurotransmitters these neurons could release and suggest how this would be accomplished.

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The researcher should test the neurons f...

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The sequence of events in chemical neurotransmission normally occurs in this order:


A) Storage, release, bind to receptors, synthesis.
B) Synthesis, storage, release, bind to receptors.
C) Release, synthesis, storage, bind to receptors.
D) Bind to receptors, release, storage, synthesis.

E) A) and D)
F) B) and C)

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A compound that blocked vesicular transporters would likely:


A) increase the activity of postsynaptic receptors.
B) cause a decrease in calcium influx.
C) prevent reuptake.
D) prevent the storage of neurotransmitters in vesicles.

E) None of the above
F) A) and D)

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At the beginning of the refractory period,why does the charge within a neuron from positive to negative?


A) An inhibitory postsynaptic potential is produced.
B) Sodium channels open allowing sodium to leave the neuron.
C) Potassium channels open allowing potassium to leave the neuron.
D) The concentration of negatively charged proteins increases.

E) B) and C)
F) A) and B)

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A drug that inhibited acetylcholinesterase would:


A) reduce levels of dopamine.
B) prevent a decrease in levels of acetylcholine.
C) increase levels of norepinephrine.
D) decrease activation of cholinergic receptors.

E) B) and C)
F) None of the above

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If a pharmacologist designed a drug that prevented the activation of G-proteins,which of the following would occur if a neurotransmitter binded to a metabotropic receptor?


A) Effector enzymes attached to the receptor would still be activated.
B) No effects would occur.
C) A second messenger would attach to the receptor.
D) Gene expression would increase.

E) A) and B)
F) A) and C)

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After the activation of a G-protein,the sequence of signalling events consists of:


A) effector enzyme, second messenger, protein kinase, substrate protein.
B) second messenger, effector enzyme, protein kinase substrate protein.
C) effector enzyme, protein kinase, second messenger, substrate protein.
D) substrate protein, protein kinase, second messenger, effector enzyme.

E) All of the above
F) B) and C)

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Describe the ways that hormones differ from neurotransmitters.

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Hormones have widespread effects on targ...

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Tyrosine hydroxylase serves as the _____________ step for dopamine.

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The following statements for serotonin are true except:


A) Serotonin has a different synthesis pathway than norepinephine.
B) Serotonin transported into vesicles through a different vesicular transporter than dopamine.
C) MAO is a catabolic enzyme for serotonin.
D) Reuptake for serotonin occurs via the serotonin transporter.

E) None of the above
F) B) and C)

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Name and describe the two pharmacological strategies for treating Alzheimer's disease that were described in the book.

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By inhibiting acetylcholinesterase,acety...

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Activating a GABAA postsynaptic receptor will cause a(n)_____________.

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inhibitory...

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A series of action potentials occurring down the length of an axon are referred to as:


A) nodes of Ranvier.
B) propagation of actions potentials.
C) firing rate.
D) the all-or-none law.

E) A) and B)
F) B) and D)

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All of the following describe conditions that facilitate an action potential except:


A) a resting potential precedes an action potential.
B) sodium channels open.
C) sodium-potassium pump activity decreases.
D) the local potential becomes depolarized.

E) A) and B)
F) A) and C)

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Ionotropic receptors are similar to voltage-gated ion channels except that:


A) the ion channels are opened when a neurotransmitters binds to the receptor.
B) there is not an ion channel.
C) hyperpolization opens the receptor channels.
D) neurotransmitters pass through the channel instead of ions.

E) C) and D)
F) A) and B)

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All of the following are examples of functions of a metabotropic receptor except:


A) gene expression and protein synthesis may occur after a neurotransmitter binds to the receptor.
B) a G-protein acts on ions channels or effector enzymes after a neurotransmitter bind to the receptor.
C) a G-protein may act on an effector enzyme that may then activate a second messenger.
D) an ion channel attached to the receptor will open when a neurotransmitter binds to the receptor.

E) None of the above
F) A) and B)

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The _______________ states that the magnitude of an action potential is independent from the magnitude of potential change that elicited the action potential.


A) concentration gradient principle
B) principle of electrostatic attraction
C) refractory period
D) all-or-none law

E) A) and B)
F) All of the above

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Potassium ions will exit a neuron during a resting potential through open channels due to:


A) electrostatic attraction.
B) a concentration gradient.
C) sodium-potassium pump activity.
D) hyperpolarization.

E) None of the above
F) A) and D)

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A neurotransmitter receptor is an example of a ligand-gated receptor.

A) True
B) False

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