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What is responsible for primary Down syndrome?


A) Disomy
B) Inversion
C) Nondisjunction
D) Polyploidy
E) Translocation

F) D) and E)
G) B) and C)

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Most strains of cultivated bananas were created by crossing plants within and between two diploid species: Musa acuminata (genome = AA) and Musa balbisiana (genome = BB) .The Cavendish banana (genome = AAA) , the variety most often sold in grocery stores, has what type of genome?


A) Allodiploid
B) Allotriploid
C) Autotriploid
D) Allotetraploid
E) Autotetraploid

F) C) and D)
G) B) and E)

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An explorer stumbled upon a remote valley and found plants that produced a colorful, sweet fruit.Many of these plants were autopolyploid and came in varieties that differed by their ploidy and the size of fruit that was produced.Which of the following plant genomes would MOST likely produce sterile plants?


A) Diploid (2n)
B) Triploid (3n)
C) Tetraploid (4n)
D) Hexaploid (6n)
E) Octaploid (8n)

F) C) and D)
G) A) and E)

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A constriction or gap at particular locations on a chromosome that is prone to breakage under certain conditions is called:


A) chromosome inversion.
B) fragile site.
C) copy-number variation.
D) nondisjunction.
E) aneuploidy.

F) A) and B)
G) A) and C)

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Duchenne muscular dystrophy (DMD)is normally an X-linked recessive human disease affecting boys.Girls afflicted with DMD are rare.Cytogenetic studies of several girls with DMD have in each case revealed that these individuals carry X-autosome translocations.The autosomes vary, but the breakpoint on the X in every case is in band p21, which is the location of the DMD gene.Cytogenetic studies further revealed that in all cells studied in such DMD girls the normal X chromosome exists as a Barr body.How might these observations account for the existence of DMD-affected girls? Why is only the normal X seen as a Barr body?

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The translocation breakpoint likely fall...

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Chimpanzees, gorillas, and orangutans all have 48 chromosomes, whereas humans have 46 chromosomes.Human chromosome 2 is a large, metacentric chromosome with G-banding patterns that closely match those found on two different acrocentric chromosomes of the apes.What would BEST explain these findings?


A) A translocation took place in a human ancestor, creating a large metacentric chromosome from the two long arms of the ancestral acrocentric chromosomes.The other small chromosome produced by this translocation was lost.
B) Meiotic nondisjunction gave rise to a nullisomic gamete.The fusion of two nullisomic gametes produced the ancestor of the human species with 46 chromosomes instead of 48 chromosomes.
C) A nonreciprocal translocation and subsequent fusion of the chromosomal fragments created a genome of 46 chromosomes without the loss of any genetic information.
D) Infection by a primate virus created a new chromosome when the viral DNA became a permanent part of the genome.Humans were not affected by this virus, so they did not acquire the extra chromosome.
E) Humans have the correct number of chromosomes.The extra chromosome pair in the other apes is a classic case of tetrasomy as a result of meiotic nondisjunction in the primate ancestor.

F) A) and E)
G) D) and E)

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Wild-type Arabidopsis has five chromosomes (2n = 10) .Trisomic plants are designated as Tr followed by the trisomic chromosome number-that is, Tr1 is trisomic for chromosome 1.Assuming that trisomy is fully viable and that all possible pairing configurations (including nonpairing) are possible at meiosis, what proportion of the progeny from the cross wt × Tr1;Tr2 will have a wild-type chromosomal complement?


A) 1/2
B) 1/3
C) 1/4
D) 1/9
E) 1/81

F) A) and B)
G) A) and C)

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Which type of chromosome mutation decreases the amount of genetic material?


A) Deletion
B) Duplication
C) Inversion
D) Translocation
E) Transversion

F) A) and B)
G) D) and E)

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What would be the consequence of a diploid gamete (resulting from meiotic nondisjunction) being fertilized by a haploid gamete from the same species?


A) Allodiploid
B) Allotriploid
C) Autotriploid
D) Allotetraploid
E) Autotetraploid

F) C) and D)
G) A) and D)

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