Question 1

Where is a gene designated 9p23 located?

Accepted Answer

A)   Short arm of chromosome 23, region 9
B)   Long arm of chromosome 3, region 2, band 9
C)   Short arm of chromosome 9, region 2, band 3
D)   On the translocated part of chromosome 9 on chromosome 23E) A) and B)
F) A) and C)

Question 2

What is the best method for detecting chromosomal material that has been structurally altered?

Accepted Answer

A)   Fluorescence in situ hybridization (FISH) 
B)   G banding
C)   Q banding
D)   Ag-NOR bandingE) All of the above
F) A) and C)

Question 3

Nonrandom chromosomal abnormalities are:

Accepted Answer

A)   Congenital chromosome abnormalities that are consistently found in all tissues of an affected individual
B)   Acquired chromosome abnormalities that are found in the abnormal or malignant tissue of an affected individual
C)   Acquired chromosome abnormalities that are found in all tissues of an affected individual
D)   Congenital chromosome abnormalities that are found in only one type of tissue of an affected individualE) None of the above
F) A) and D) B

Question 4

A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons except:

Accepted Answer

A)   To provide unique cytogenetic profile to confirm the patient's identification
B)   To provide diagnostic information
C)   To identify whether the patient will respond to appropriate therapy
D)   To provide prognostic informationE) A) and C)
F) A) and B) A

Question 5

Cytogenetics is performed on the bone marrow of a patient, and 20 cells are examined. The patient's karyotype is reported as 47, XX, +7(14) , indicating that:

Accepted Answer

A)   This is a female patient with trisomy chromosome 7 found in 14 of the cells examined.
B)   This is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined.
C)   This is a male patient with trisomy 7 found in 1 of 4 cells examined.
D)   This is a male patient with monosomy 7 found in 14 of the cells examined.E) A) and B)
F) All of the above A

Question 6

All of the following samples are commonly analyzed for chromosomes except:

Accepted Answer

A)   Bone marrow
B)   Amniotic fluid
C)   Peripheral lymphocytes
D)   Tissue with a low mitotic rateE) All of the above
F) B) and C)

Question 7

What tissue is most often studied for hematologic malignancies?

Accepted Answer

A)   Peripheral blood
B)   Bone marrow
C)   Spleen
D)   Lymph node sectionsE) A) and B)
F) A) and C)

Question 8

A break in two chromosomes with each piece uniting with different chromosomes is called:

Accepted Answer

A)   Deletion
B)   Duplication
C)   Insertion
D)   TranslocationE) A) and C)
F) B) and D)

Question 9

The period in the cell cycle when deoxyribonucleic acid (DNA)  is synthesized is:

Accepted Answer

A)   G1
B)   S
C)   G2
D)   ME) A) and B)
F) A) and C)

Question 10

What happens to nuclear chromatin at mitosis?

Accepted Answer

A)   Opens
B)   Condenses
C)   Disappears
D)   Develops nucleoliE) A) and D)
F) None of the above

Question 11

Cell division to produce daughter cells identical to the parent cell is an example of:

Accepted Answer

A)   Nondisjunction
B)   Meiosis
C)   Mitosis
D)   Gamete productionE) None of the above
F) A) and B)

Question 12

A chromosome number that is not a multiple of the haploid number is:

Accepted Answer

A)   Aneuploidy
B)   Mosaic
C)   Polyploidy
D)   Incompatible with lifeE) All of the above
F) None of the above

Question 13

Which of the following is true regarding the number of chromosomes of different species?

Accepted Answer

A)   All mammals have the same number.
B)   Numbers vary greatly among mammals unrelated to characteristics.
C)   Primates have more than lower mammals.
D)   Primates have fewer than lower mammals.E) All of the above
F) None of the above

Question 14

All of the following disorders are associated with acquired chromosome abnormalities except:

Accepted Answer

A)   Megaloblastic anemia
B)   Chronic myelogenous leukemia
C)   Acute myeloid leukemia
D)   Acute lymphoblastic leukemiaE) A) and D)
F) B) and D)

Question 15

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

Accepted Answer

A)   Trisomy 8
B)   Deletion 7
C)   Philadelphia
D)   Isocentric chromosome 16E) C) and D)
F) A) and D)

Question 16

How many chromosomes does a human with triploidy have?

Accepted Answer

A)   3
B)   23
C)   47
D)   69E) B) and D)
F) A) and B)

Question 17

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

Accepted Answer

A)   Sexual ambiguity
B)   Myeloid leukemia
C)   Mental retardation
D)   Usually incompatibility with lifeE) None of the above
F) A) and D)

Exam 31: Cytogenetics

Where is a gene designated 9p23 located?

Correct Answer
verified

What is the best method for detecting chromosomal material that has been structurally altered?

Correct Answer
verified

Nonrandom chromosomal abnormalities are:

Correct Answer
verified
B

A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons except:

Correct Answer
verified
A

Cytogenetics is performed on the bone marrow of a patient, and 20 cells are examined. The patient's karyotype is reported as 47, XX, +7(14) , indicating that:

Correct Answer
verified
A

All of the following samples are commonly analyzed for chromosomes except:

Correct Answer
verified

What tissue is most often studied for hematologic malignancies?

Correct Answer
verified

A break in two chromosomes with each piece uniting with different chromosomes is called:

Correct Answer
verified

The period in the cell cycle when deoxyribonucleic acid (DNA) is synthesized is:

Correct Answer
verified

What happens to nuclear chromatin at mitosis?

Correct Answer
verified

Cell division to produce daughter cells identical to the parent cell is an example of:

Correct Answer
verified

A chromosome number that is not a multiple of the haploid number is:

Correct Answer
verified

Which of the following is true regarding the number of chromosomes of different species?

Correct Answer
verified

All of the following disorders are associated with acquired chromosome abnormalities except:

Correct Answer
verified

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

Correct Answer
verified

How many chromosomes does a human with triploidy have?

Correct Answer
verified

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

Correct Answer
verified

Exam 31: Cytogenetics

Where is a gene designated 9p23 located?

Correct AnswerverifiedShow Answer

What is the best method for detecting chromosomal material that has been structurally altered?

Correct AnswerverifiedShow Answer

Nonrandom chromosomal abnormalities are:

Correct AnswerverifiedB

A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons except:

Correct AnswerverifiedA

Cytogenetics is performed on the bone marrow of a patient, and 20 cells are examined. The patient's karyotype is reported as 47, XX, +7(14) , indicating that:

Correct AnswerverifiedA

All of the following samples are commonly analyzed for chromosomes except:

Correct AnswerverifiedShow Answer

What tissue is most often studied for hematologic malignancies?

Correct AnswerverifiedShow Answer

A break in two chromosomes with each piece uniting with different chromosomes is called:

Correct AnswerverifiedShow Answer

The period in the cell cycle when deoxyribonucleic acid (DNA) is synthesized is:

Correct AnswerverifiedShow Answer

What happens to nuclear chromatin at mitosis?

Correct AnswerverifiedShow Answer

Cell division to produce daughter cells identical to the parent cell is an example of:

Correct AnswerverifiedShow Answer

A chromosome number that is not a multiple of the haploid number is:

Correct AnswerverifiedShow Answer

Which of the following is true regarding the number of chromosomes of different species?

Correct AnswerverifiedShow Answer

All of the following disorders are associated with acquired chromosome abnormalities except:

Correct AnswerverifiedShow Answer

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

Correct AnswerverifiedShow Answer

How many chromosomes does a human with triploidy have?

Correct AnswerverifiedShow Answer

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

Correct AnswerverifiedShow Answer

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B

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A

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A

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